_______________The Other 90% of Science_______________

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Hwang WS et al

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Science 2005 Jun 17;308(5729):1777-83      
Patient-specific embryonic stem cells derived from human SCNT blastocysts.


Chisaka O and Capecchi MR

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Nature 1991 Apr 11;350(6318):473-9      
Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5.


Won J et al

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Nat Chem Biol 2006 Jul;2(7):369-74      
Small molecule-based reversible reprogramming of cellular lifespan.


Taylor NP et al

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Cancer Res 2006 Aug 1;66(15):7502-8      
MLH3 mutation in endometrial cancer.


Rubio-Viqueira B et al

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Clin Cancer Res 2006 Aug 1;12(15):4652-61      
An in vivo platform for translational drug development in pancreatic cancer.


Dewan A et al

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Science 2006 Nov 10;314(5801):989-92      
HTRA1 promoter polymorphism in wet age-related macular degeneration.


Liu R et al

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N Engl J Med 2007 Jan 18;356(3):217-26      
The prognostic role of a gene signature from tumorigenic breast-cancer cells.


Souglakos J et al

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Dig Dis 2007;25(1):100-5      
Irinotecan plus weekly 5-fluorouracil and leucovorin as salvage treatment for patients with metastatic colorectal cancer: a phase II trial.


Yeager M et al

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Nat Genet 2007 May;39(5):645-9      
Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.


Rioux JD et al

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Nat Genet 2007 May;39(5):596-604      
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis.


Jerne NK and Nordin AA

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Science 1963 Apr 26;140(3565):405      
Plaque Formation in Agar by Single Antibody-Producing Cells.


Srivastava JK and Gupta S

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J Agric Food Chem 2007 Nov 14;55(23):9470-8      
Antiproliferative and apoptotic effects of chamomile extract in various human cancer cells.


Milne JC et al

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Nature 2007 Nov 29;450(7170):712-6      
Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.


Nair RR et al

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A novel high-throughput screening system identifies a small molecule repressive for matrix metalloproteinase-9 expression.


Yonish-Rouach E et al

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Nature 1991 Jul 25;352(6333):345-7      
Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6.


Sun GP et al

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Dis Esophagus 2008;21(8):723-9      
Antiproliferation and apoptosis induction of paeonol in human esophageal cancer cell lines.


Roy HK et al

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Spectral slope from the endoscopically-normal mucosa predicts concurrent colonic neoplasia: a pilot ex-vivo clinical study.


Stampfer MJ et al

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N Engl J Med 1991 Sep 12;325(11):756-62      
Postmenopausal estrogen therapy and cardiovascular disease. Ten-year follow-up from the nurses' health study.


Simeone DM

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Clin Cancer Res 2008 Sep 15;14(18):5646-8      
Pancreatic cancer stem cells: implications for the treatment of pancreatic cancer.


Nolen B et al

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Gynecol Oncol 2009 Jan;112(1):47-54      
A serum based analysis of ovarian epithelial tumorigenesis.


Kopetz S et al

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Cancer Res 2009 May 1;69(9):3842-9      
Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress.


Diede SJ et al

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Proc Natl Acad Sci U S A 2010 Jan 5;107(1):234-9      
DNA methylation of developmental genes in pediatric medulloblastomas identified by denaturation analysis of methylation differences.


Clarke R et al

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N Engl J Med 1991 Apr 25;324(17):1149-55      
Hyperhomocysteinemia: an independent risk factor for vascular disease.


Halaban R et al

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Pigment Cell Melanoma Res 2010 Apr;23(2):190-200      
PLX4032, a selective BRAF(V600E) kinase inhibitor, activates the ERK pathway and enhances cell migration and proliferation of BRAF melanoma cells.


Schaeffer HJ et al

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Nature 1978 Apr 13;272(5654):583-5      
9-(2-hydroxyethoxymethyl) guanine activity against viruses of the herpes group.


Lee JH et al

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Proc Natl Acad Sci U S A 2010 Aug 17;107(33):14639-44      
Histone deacetylase inhibitor induces DNA damage, which normal but not transformed cells can repair.


Valeri N et al

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Proc Natl Acad Sci U S A 2010 Dec 7;107(49):21098-103      
MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2).


Tan WL et al

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Cancer Biol Ther 2011 Mar 15;11(6):599-608      
Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.


Ceol CJ et al

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Nature 2011 Mar 24;471(7339):513-7      
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset.


Huryn DM et al

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Proc Natl Acad Sci U S A 2011 Apr 26;108(17):6757-62      
Chemical methodology as a source of small-molecule checkpoint inhibitors and heat shock protein 70 (Hsp70) modulators.


Vignoli M et al

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Pharmacol Res 2011 Sep;64(3):242-8      
Thymidylate synthase expression and genotype have no major impact on the clinical outcome of colorectal cancer patients treated with 5-fluorouracil.


Hockenbery D et al

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Nature 1990 Nov 22;348(6299):334-6      
Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death.


Thomas JO and Kornberg RD

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Proc Natl Acad Sci U S A 1975 Jul;72(7):2626-30      
An octamer of histones in chromatin and free in solution.


Nakamura T et al

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Nature 1989 Nov 23;342(6248):440-3      
Molecular cloning and expression of human hepatocyte growth factor.


Ignarro LJ et al

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Proc Natl Acad Sci U S A 1987 Dec;84(24):9265-9      
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.


Mansour SL et al

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Nature 1988 Nov 24;336(6197):348-52      
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes.


Ptashne M

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Nature 1967 Apr 15;214(5085):232-4      
Specific binding of the lambda phage repressor to lambda DNA.


Gallo RC et al

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Science 1984 May 4;224(4648):500-3      
Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.


Kägi D et al

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Science 1994 Jul 22;265(5171):528-30      
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicity.


Yang E et al

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Cell 1995 Jan 27;80(2):285-91      
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.


Peters WP et al

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J Clin Oncol 1993 Jun;11(6):1132-43      
High-dose chemotherapy and autologous bone marrow support as consolidation after standard-dose adjuvant therapy for high-risk primary breast cancer.


Blasco MA et al

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Cell 1997 Oct 3;91(1):25-34      
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA.


Gelband CH et al

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Hypertension 1999 Jan;33(1 Pt 2):360-5      
Angiotensin II type 1 receptor antisense gene therapy prevents altered renal vascular calcium homeostasis in hypertension.


Kleeff J et al

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Gastroenterology 1999 May;116(5):1202-16      
Bone morphogenetic protein 2 exerts diverse effects on cell growth in vitro and is expressed in human pancreatic cancer in vivo.


Venter JC et al

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Science 2001 Feb 16;291(5507):1304-51      
The sequence of the human genome.


Culmsee C et al

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J Neurochem 2001 Apr;77(1):220-8      
A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.


Pepe MS et al

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J Natl Cancer Inst 2001 Jul 18;93(14):1054-61      
Phases of biomarker development for early detection of cancer.


Pedersen MW et al

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Ann Oncol 2001 Jun;12(6):745-60      
The type III epidermal growth factor receptor mutation. Biological significance and potential target for anti-cancer therapy.


Sartippour MR et al

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Oncol Rep 2001 Nov-Dec;8(6):1355-7      
Livistona extract inhibits angiogenesis and cancer growth.


Zhao X et al

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Cancer Res 2001 Oct 15;61(20):7383-7      
A novel growth suppressor gene on chromosome 17p13.3 with a high frequency of mutation in human hepatocellular carcinoma.


Welsh CF et al

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Nat Cell Biol 2001 Nov;3(11):950-7      
Timing of cyclin D1 expression within G1 phase is controlled by Rho.



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J Biol Chem 1962 May;237:1555-62      
Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the new-born animal.


Kohli M et al

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Nucleic Acids Res 2004 Jan 2;32(1):e3      
Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses.


Dhir R et al

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J Urol 2004 Apr;171(4):1419-23      
Early identification of individuals with prostate cancer in negative biopsies.


Mombaerts P et al

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Cell 1992 Mar 6;68(5):869-77      
RAG-1-deficient mice have no mature B and T lymphocytes.


Mor G et al

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Proc Natl Acad Sci U S A 2005 May 24;102(21):7677-82      
Serum protein markers for early detection of ovarian cancer.


Kang Y et al

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Proc Natl Acad Sci U S A 2005 Sep 27;102(39):13909-14      
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway.


Viswanathan M et al

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Dev Cell 2005 Nov;9(5):605-15      
A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.


Zhang X et al

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Hum Mutat 2006 Jan;27(1):110-7      
Genetic polymorphisms in cell cycle regulatory genes MDM2 and TP53 are associated with susceptibility to lung cancer.


Pagès F et al

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N Engl J Med 2005 Dec 22;353(25):2654-66      
Effector memory T cells, early metastasis, and survival in colorectal cancer.


Michl J et al

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Int J Cancer 2006 Oct 1;119(7):1577-85      
PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo.


Yoon A et al

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Science 2006 May 12;312(5775):902-6      
Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita.


Mozaffarian D and Rimm EB

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JAMA 2006 Oct 18;296(15):1885-99      
Fish intake, contaminants, and human health: evaluating the risks and the benefits.


Stupp R and Hegi ME

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J Clin Oncol 2007 Apr 20;25(12):1459-60      
Methylguanine methyltransferase testing in glioblastoma: when and how?


Levy L et al

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Mol Cell Biol 2007 Sep;27(17):6068-83      
Arkadia activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation.


Hao Y et al

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BMC Gastroenterol 2007 Jun 27;7:24      
Gene expression changes associated with Barrett's esophagus and Barrett's-associated adenocarcinoma cell lines after acid or bile salt exposure.


Ray PS and Fox PL

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EMBO J 2007 Jul 25;26(14):3360-72      
A post-transcriptional pathway represses monocyte VEGF-A expression and angiogenic activity.


Pfeiffer T and Hoffmann R

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Proc Natl Acad Sci U S A 2007 Jul 17;104(29):12052-6      
Temporal patterns of genes in scientific publications.


Tavazoie SF et al

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Nature 2008 Jan 10;451(7175):147-52      
Endogenous human microRNAs that suppress breast cancer metastasis.


Lutsey PL et al

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Circulation 2008 Feb 12;117(6):754-61      
Dietary intake and the development of the metabolic syndrome: the Atherosclerosis Risk in Communities study.


Bodmer W

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Cancer Res 2008 May 15;68(10):3558-60; di      
Genetic instability is not a requirement for tumor development.


Sobczak I et al

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Oncogene 2008 Aug 14;27(35):4779-87      
B-Raf is required for ERK activation and tumor progression in a mouse model of pancreatic beta-cell carcinogenesis.


Kawai S et al

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Cancer Sci 2008 Dec;99(12):2461-6      
Interferon-alpha enhances CD317 expression and the antitumor activity of anti-CD317 monoclonal antibody in renal cell carcinoma xenograft models.


Garman KS et al

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Proc Natl Acad Sci U S A 2008 Dec 9;105(49):19432-7      
A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.


Kaplan N et al

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Nature 2009 Mar 19;458(7236):362-6      
The DNA-encoded nucleosome organization of a eukaryotic genome.


Talasaz AH et al

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Proc Natl Acad Sci U S A 2009 Mar 10;106(10):3970-5      
Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device.


Rhodes DR et al

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Proc Natl Acad Sci U S A 2009 Jun 23;106(25):10284-9      
AGTR1 overexpression defines a subset of breast cancer and confers sensitivity to losartan, an AGTR1 antagonist.


Heidorn SJ et al

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Cell 2010 Jan 22;140(2):209-21      
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.


Kasowski M et al

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Science 2010 Apr 9;328(5975):232-5      
Variation in transcription factor binding among humans.


Di LJ et al

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Nat Struct Mol Biol 2010 Nov 21;      
Transcriptional regulation of BRCA1 expression by a metabolic switch.


Culler SJ et al

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Science 2010 Nov 26;330(6008):1251-5      
Reprogramming cellular behavior with RNA controllers responsive to endogenous proteins.


Antonyak MA et al

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Proc Natl Acad Sci U S A 2011 Mar 22;108(12):4852-7      
Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells.


Wright NA et al

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Nature 1990 Jan 4;343(6253):82-5      
Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells.


Nakamura Y et al

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Science 1987 Mar 27;235(4796):1616-22      
Variable number of tandem repeat (VNTR) markers for human gene mapping.


MacDonald HR et al

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Nature 1988 Mar 3;332(6159):40-5      
T-cell receptor V beta use predicts reactivity and tolerance to Mlsa-encoded antigens.


Barré-Sinoussi F et al

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Science 1983 May 20;220(4599):868-71      
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).


Tsien RY

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Biochemistry 1980 May 27;19(11):2396-404      
New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures.


Resnicoff M et al

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Cancer Res 1995 Sep 1;55(17):3739-41      
Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors.


Kumar MS et al

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Biochemistry 2002 Oct 1;41(39):11681-91      
Structures of apolipoprotein A-II and a lipid-surrogate complex provide insights into apolipoprotein-lipid interactions.


Barratt PL et al

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Lancet 2002 Nov 2;360(9343):1381-91      
DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study.


Grippo PJ et al

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Cancer Res 2003 May 1;63(9):2016-9      
Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant Kras in transgenic mice.


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Anal Sci 2004 Jun;20(6):971-4      
Influence of the pH on separating DNA by high-speed microchip electrophoresis.


Miller LD et al

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Proc Natl Acad Sci U S A 2005 Sep 20;102(38):13550-5      
An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival.


Arnold K et al

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Cancer Lett 2006 Nov 8;243(1):90-100      
Lower level of BRCA2 protein in heterozygous mutation carriers is correlated with an increase in DNA double strand breaks and an impaired DSB repair.


Fu X et al

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J Biol Chem 2006 Jul 21;281(29):20368-82      
cAMP-response element-binding protein mediates acid-induced NADPH oxidase NOX5-S expression in Barrett esophageal adenocarcinoma cells.


Malik M et al

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Mol Cancer Ther 2006 Jun;5(6):1405-14      
Roles of nonhomologous end-joining pathways in surviving topoisomerase II-mediated DNA damage.


Mantzoros CS et al

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Eur J Cancer 2007 Jun;43(9):1430-6      
Circulating adiponectin levels in relation to melanoma: a case-control study.


Ahmed FE et al

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Cancer Genomics Proteomic 2007 Jan-Feb;4(1):1-20      
Transcriptomic molecular markers for screening human colon cancer in stool and tissue.


Nakahara T et al

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Cancer Res 2007 Sep 1;67(17):8014-21      
YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts.


Blecharz-Klin K et al

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Acta Neurobiol Exp (Wars) 2009;69(2):217-31      
Pharmacological and biochemical effects of Ginkgo biloba extract on learning, memory consolidation and motor activity in old rats.

Authors represented in these publications:

Abraham D, Acharya CR, Adams MD, Agelaki S, Ahmed FE, Alarcón C, Androulakis N, Antonyak MA, Arlotti J, Arnold K, Assoian RK, Ateeq B, Avila H, Azuma Y, Baba Y, Baccarini M, Bacchiocchi A, Backman V, Barnstable C, Barratt PL, Barré-Sinoussi F, Baserga R, Bast RC Jr, Bauer DJ, Beauchamp L, Beer DG, Behar J, Berdichevsky A, Berger A, Bergh J, Bhattacharya B, Birbeck K, Blasberg R, Blasco MA, Blecharz-Klin K, Bodmer W, Boise LH, Boroughs LK, Bos PD, Boyd DD, Braconi C, Brandenburger Y, Brandt-Rauf P, Brant SR, Bray-Ward P, Brodsky JL, Brummond KM, Bryant KL, Buga GM, Burgaud JL, Byrns RE, Büchler MW, COHEN S, Cahalane S, Camus M, Cao Q, Cao W, Capecchi MR, Carson M, Ceol CJ, Cerione RA, Chandra J, Chang KY, Chanock SJ, Chaudhuri G, Chen GY, Chermann JC, Chinnaiyan AM, Chisaka O, Cho JH, Choy ML, Christofori G, Chrousos GP, Clarke MF, Clarke R, Colditz GA, Collins P, Croce CM, Culler SJ, Culmsee C, Cusatis G, Dallas NA, Daly L, Daly MJ, Damstrup L, Darnay BG, Das D, Davis RW, De Siervi A, DePinho RA, Demeure MJ, Dewan A, Dhir R, Di LJ, Diede SJ, Edelman E, Elia G, Elion GB, Elliott PJ, Ellis LM, Enriquez-Rios V, Episkopou V, Etzioni R, Evans J, Feng Z, Fernandez AG, Festenstein H, Fichtner I, Fine RL, Fishel R, Fondufe-Mittendorf Y, Foster SS, Fowler B, Fox PL, Frerk K, Fridman WH, Friess H, Fu X, Fujii E, Fujimoto E, Galabova-Kovacs G, Gallick GE, Gallo RC, Galon J, Gardner K, Garman KS, Garraway LA, Gasparini P, Gelband CH, Geng LN, Genuardi M, George J, Georgoulias V, Gerald WL, Gerstein MB, Getzenberg RH, Gibb RK, Go VL, Gogas H, Golstein P, Goodfellow PJ, Gorelik E, Graham I, Greider CW, Greig NH, Grippo PJ, Grubert F, Gu J, Guarente L, Guenthoer J, Guo Y, Guo Z, Gupta S, Hagiya M, Halaban R, Hande MP, Hao Y, Harkin S, Hartman S, Hasabou N, Hayes RB, He W, He Y, Heber D, Heffelfinger C, Hegi ME, Heidorn SJ, Hengartner H, Hennekens CH, Herrup K, Hidalgo M, Hill CS, Hockenbery D, Hoff KG, Hoff M, Hoffmann R, Hoh J, Holowka DA, Houvras Y, Howell M, Hruban RH, Hsu D, Huber DE, Hunter DJ, Huryn DM, Hussain MM, Hwang WS, Iacomini J, Iacopetta B, Ignarro LJ, Ishiwata T, Jameel M, Jane-Valbuena J, Jeffrey SS, Jerne NK, Jimeno A, Jirousek MR, Jockel J, Johnson RS, Jones R, Joniec I, Kalbakis K, Kang Y, Kaplan N, Kasowski M, Katovich MJ, Kawai S, Kim M, Kim MK, Kim N, Kim SK, Kim TK, Kim YL, Kimchi A, Kinoyama I, Kinzler KW, Klaar S, Kleeff J, Kluger Y, Kohli M, Kopetz S, Korbel JO, Korc M, Kornberg RD, Korsmeyer SJ, Kosaka M, Kren A, Kudoh M, Kumar MS, Kumlin E, Kägi D, Lai Y, Lambert PD, Lambeth D, Landsittel D, Lansdorp PM, Ledermann B, Lee BC, Lee HW, Lee JH, Lees RK, Lengauer C, Leppert M, Lesslie DP, Levy L, Lewicki J, Li B, Li J, Lieb JD, Lin D, Liu C, Liu ET, Liu M, Liu R, Liu SH, Liu Y, Loh M, Lokshin A, Longnecker DS, Longo DL, Lotem J, Lowe AW, Lucas PC, Lutsey PL, Ma X, MacDonald HR, Maitra A, Malik M, Mansour SL, Mantzoros CS, Marais R, Marcuard SP, Marks PA, Marrangoni A, Maruyama H, Massagué J, Masterson R, Matsumoto T, Mattson 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