BioMed Critical Commentary™

_______________The Other 90% of Science_______________

View Linked Comments
PMID: 17554261

Parkes M et al
Nat Genet 2007 Jul;39(7):830-2
Sequence variants in the autophagy gene IRGM and multiple other replicating...

Only 1 comment exists on this article.

Not likely to be clinically useful

Rank: 1

BioMed Crit Comm 2009; 2:1484
Posted: Mar 1, 2009 CCID: 1484
Commentator: Gary	Ave. score of this commentator: 2.6 for 30 scored comments.

Jacobsdottir et al (PMID: 19197355) used five SNPs associated with risk of inflammatory bower disease, from this publication and others, to model risk assessment. Using published allele frequencies, the area under the curve (AUC) of the ROC (receiver operating curve, a plot of the true-positive fraction and false-positive fraction) was only a modest 0.66. This is well below the level needed for an assay to provide useful clinical risk classifications for individual patients.

Key authors in this publication:

Barrett JC, Cardon L, Mansfield JC, Mathew CG, Parkes M, Prescott NJ.

View Linked Comments	PMID: 17554261
Parkes M et al Nat Genet 2007 Jul;39(7):830-2 Sequence variants in the autophagy gene IRGM and multiple other replicating...