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PMID: 20133829

Bovee JV
Proc Natl Acad Sci U S A 2010 Feb 2;107(5):1813-4
EXTra hit for mouse osteochondroma.

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Wrong citation of Knudson

Rank: 1

BioMed Crit Comm 2010; 3:2270
Posted: Dec 30, 2010 CCID: 2270
Commentator: CancerMan	Ave. score of this commentator: 2.6 for 278 scored comments.

Author Judith Bovee discusses whether osteocondromas require loss of function mutations affecting both, or instead only one, copy of an EXT gene. To provide a mechanistic explanation of the difference, she cites Knudson (PMID: 5279523 CC), writing "According to Knudson's two-hit model (3)...both alleles of EXT would need to be inactivated." This is not correct, on two levels. First, her reference #3 refers to Knudson's 1971 paper, which was years before Knudson first discussed the possibility that both hits might affect the same gene (see CCID: 3). The possibility that two hits would affect differing genes, which was the premise for Knudson's 1971 paper, is a concept having nothing to do with the topic under discussion by Bovee. Second, Knudson first discussed the allelic 2-hit recessive gene theory in 1973 Adv Cancer Res 17:317, and in doing so gave credit for the proposal to Nicholls in1969 Hum Heredity 19:473-479 (PMID: 4984127). The two-hit model referred to by Bovee is Nicholls' model, which Knudson acknowledged and later popularized. It is not Knudson's model.

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Bovee JV.

View Linked Comments	PMID: 20133829
Bovee JV Proc Natl Acad Sci U S A 2010 Feb 2;107(5):1813-4 EXTra hit for mouse osteochondroma.